Differential expression of proinflammatory cytokines and their inhibitors during the course of meningococcal infections.

نویسندگان

  • M van Deuren
  • J van der Ven-Jongekrijg
  • P N Demacker
  • A K Bartelink
  • R van Dalen
  • R W Sauerwein
  • H Gallati
  • J L Vannice
  • J W van der Meer
چکیده

Circulating concentrations of tumor necrosis factor-alpha (TNF), interleukin (IL)-1 beta, IL-6, IL-1 receptor antagonist (IL-1ra), and soluble TNF receptors p55 (sTNFr-55) and p75 (sTNFr-75) and ex vivo production of TNF, IL-1, IL-6, and IL-1ra using a whole blood culture system were measured during the acute and convalescent stages of meningococcal infection. Circulating TNF and IL-1 were below detection level, whereas IL-6 and IL-1ra, sTNFr-55, and sTNFr-75 were increased at admission. The ex vivo production of proinflammatory cytokines TNF, IL-1, and IL-6 was suppressed at admission and restored gradually during recovery. On the contrary, the production of the antiinflammatory IL-1ra was increased at admission. The elevated concentrations of both IL-1ra and sTNFr early in the course of infection suggest a regulatory role for these antiinflammatory compounds. The observed down-regulation of the ex vivo production of TNF, IL-1, and IL-6 and up-regulation of the production of IL-1ra in the acute stage may indicate a protective regulation mechanism.

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Proinflammatory and anti-inflammatory cytokines in meningococcal disease.

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عنوان ژورنال:
  • The Journal of infectious diseases

دوره 169 1  شماره 

صفحات  -

تاریخ انتشار 1994